The start of pregnancy certainly involves being extra-tired and possibly extra-sleepy (the two were hard to distinguish for me): could that be the sedating part?
I've been meaning to ask this, and these threads are probably the best place. My partner gets bad PMS. 3rd week of her cycle more generally, but almost from the 15th day to the 18th day or so she's very anxious, she starts feeling bad about things, fails to connect it to her cycle so follows the bad feelings further and generally has a bad time. The usual internet advice around exercise and sleep etc is not particularly useful. Is there a good way to handle the hormonal shifts going on for her?
Interesting, 15th to 18th day is in luteal phase so progesterone levels will be high. It's too early to be considered PMS but there could be something else going on.
Unfortunately I don't have any advice for you, but maybe there's an endocrinologist somewhere who has better insight.
Not really any useful advice, apart from (1) B complex vitamins, they do help with your mental state (2) iron supplements, most women don't get enough and (3) check out her electrolyte balance, I find that things like having your potassium or magnesium levels out of whack also affects mood.
(I didn't get anxious but I did get very snappy and short-tempered and more prone to violence, for what it's worth).
I got prescribed progesterone (medroxyprogesterone IIRC) for the situation you’re describing (third week timing) and it helped a lot. I don’t recall the dose. Oral administration helped; topical helped less.
Not taking it anymore, miss it though.
The timing of the dosing was important. I think I was taking it the last two weeks of the cycle.
Third week is supposed to be the wrong week to be miserable, but it was real. Grim anger more than depression per se. I think it’s a slightly different thing than fourth-week problems but progesterone helps with both.
Presumably they range over a much wider span of intuitive matters, that matter to far more people by a much larger amount, whereas psychiatric drugs for post-partum depression matters to a relatively small group of people and of those, the issues involved are (relatively) scientific and involve (relatively) few intuitive questions. Whereas politics can be summed up as "all the issues for which the underlying questions are not resolvable via formal scientific means, or in which some people claim they are but others disagree, or in which the actual science itself is in dispute".
Oh, a lame comment "correcting" something you didn't even say gets in, but my devastatingly clever and almost even relevant essay on opioids and depression doesn't? I see. I see how it is. No, don't try defending yourself with comments about how talk of unrelated strategies and medications isn't appropriate for a follow-up post about progesterone, I won't hear it!
Those costs are about 1000x too high for a small molecule active pharmaceutical ingredient made at scale. Typical cost of small molecule API is $5000 - $25000 per kg. Source: I've made metric tons of drug substance.
Because both in vitro fecundation and artificial insemination are unacceptable for catholics, so catholic fertility doctors needs to try different tricks.
The start of pregnancy certainly involves being extra-tired and possibly extra-sleepy (the two were hard to distinguish for me): could that be the sedating part?
I was just thinking this. The brain fog and intense mental/physical exhaustion were among the most difficult symptoms in all five of my pregnancies.
Yeah same for my spouse
I've been meaning to ask this, and these threads are probably the best place. My partner gets bad PMS. 3rd week of her cycle more generally, but almost from the 15th day to the 18th day or so she's very anxious, she starts feeling bad about things, fails to connect it to her cycle so follows the bad feelings further and generally has a bad time. The usual internet advice around exercise and sleep etc is not particularly useful. Is there a good way to handle the hormonal shifts going on for her?
Interesting, 15th to 18th day is in luteal phase so progesterone levels will be high. It's too early to be considered PMS but there could be something else going on.
Unfortunately I don't have any advice for you, but maybe there's an endocrinologist somewhere who has better insight.
Not really any useful advice, apart from (1) B complex vitamins, they do help with your mental state (2) iron supplements, most women don't get enough and (3) check out her electrolyte balance, I find that things like having your potassium or magnesium levels out of whack also affects mood.
(I didn't get anxious but I did get very snappy and short-tempered and more prone to violence, for what it's worth).
I got prescribed progesterone (medroxyprogesterone IIRC) for the situation you’re describing (third week timing) and it helped a lot. I don’t recall the dose. Oral administration helped; topical helped less.
Not taking it anymore, miss it though.
The timing of the dosing was important. I think I was taking it the last two weeks of the cycle.
Third week is supposed to be the wrong week to be miserable, but it was real. Grim anger more than depression per se. I think it’s a slightly different thing than fourth-week problems but progesterone helps with both.
>how much better the biomedical comment threads are compared to some of the others.
I think this is because the more political posts tend to attract a different style of commentary.
Presumably they range over a much wider span of intuitive matters, that matter to far more people by a much larger amount, whereas psychiatric drugs for post-partum depression matters to a relatively small group of people and of those, the issues involved are (relatively) scientific and involve (relatively) few intuitive questions. Whereas politics can be summed up as "all the issues for which the underlying questions are not resolvable via formal scientific means, or in which some people claim they are but others disagree, or in which the actual science itself is in dispute".
So maybe this isn't quite on topic but I just wanted to say I really appreciate these "Highlights From The Comments On some such" posts.
Enjoyable to read and a 'best of' for the comments as well as a nice follow up to the original post.
Agree. I appreciate the work that goes into compiling/curating them.
Oh, a lame comment "correcting" something you didn't even say gets in, but my devastatingly clever and almost even relevant essay on opioids and depression doesn't? I see. I see how it is. No, don't try defending yourself with comments about how talk of unrelated strategies and medications isn't appropriate for a follow-up post about progesterone, I won't hear it!
"Yeah, this has me confused about why pregnancy isn’t more sedating than it is."
Ummm, have you spoken to many pregnant women?
This was also my thought! I was soooo tired, and for the whole pregnancy. I never got the rumored second trimester burst of energy.
Those costs are about 1000x too high for a small molecule active pharmaceutical ingredient made at scale. Typical cost of small molecule API is $5000 - $25000 per kg. Source: I've made metric tons of drug substance.
"Catholic fertility doctors are more interested in progesterone than the mainstream" - I'm genuinely curious as to why this might be the case.
Because both in vitro fecundation and artificial insemination are unacceptable for catholics, so catholic fertility doctors needs to try different tricks.