Gwern's written-up (in impressive detail) some blinded (double-blinded?) experiments he's done with 'nootropics' if you're interested in a detailed answer.
I know this is 3.5 years late, but FWIW, the effects of kanna compounds are perceptible for me within an hour of taking it – it's nothing like traditional SSRIs. The Zembrin website says fully effective within 1-2 days.
Running a double-blind trial on yourself for a drug whose effects are meant to kick in after days or weeks seems difficult. How would you manage this?
As long as you don’t need the results quickly, just randomize in longer blocks of time (say, 2 weeks) rather than randomizing on a day-to-day level.
Gwern's written-up (in impressive detail) some blinded (double-blinded?) experiments he's done with 'nootropics' if you're interested in a detailed answer.
I know this is 3.5 years late, but FWIW, the effects of kanna compounds are perceptible for me within an hour of taking it – it's nothing like traditional SSRIs. The Zembrin website says fully effective within 1-2 days.