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do you still want people to preregister with you if they try Zembrin after reading this?

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Not really, I feel like I've exhausted what I can get from having a higher sample size for the same terrible experimental methodology. If you want to run a double-blind trial on yourself I'd be interested.

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Running a double-blind trial on yourself for a drug whose effects are meant to kick in after days or weeks seems difficult. How would you manage this?

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As long as you donтАЩt need the results quickly, just randomize in longer blocks of time (say, 2 weeks) rather than randomizing on a day-to-day level.

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Gwern's written-up (in impressive detail) some blinded (double-blinded?) experiments he's done with 'nootropics' if you're interested in a detailed answer.

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I know this is 3.5 years late, but FWIW, the effects of kanna compounds are perceptible for me within an hour of taking it тАУ it's nothing like traditional SSRIs. The Zembrin website says fully effective within 1-2 days.

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Makes sense! In that case you might want to edit the preregistration bit out of the Lorien page about Zembrin so people don't email you about it.

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Many digital platforms have adopted the https://sprunkigame.org aesthetic, offering users engaging gameplay paired with funky visuals and sounds. These games challenge playersтАЩ creativity, urging them to think outside the box.

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